ADAM28 Rabbit Polyclonal Antibody

CAT#: TA352954L

Rabbit polyclonal anti-ADAM28 antibody

Product Images

Western blot of lysates from COS-7 cells transfected with a pcDNA control and wild-type ADAM28 (WT). All samples were reduced with DTT and separated on a 7.5% (w/v) polyacrylamide gel. Proteins were transferred to nitrocellulose and immunoblotted with ADAM28 cytoplasmic domain antiserum.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ADAM28
• Concentration: lot specific
• Purification: Unpurified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~100 kDa
• Gene Name: ADAM metallopeptidase domain 28
• Database Link:
  NP_055080
  Entrez Gene 13522 MouseEntrez Gene 10863 Human
  UniProt ID Q9UKQ2
• Background: ADAM28, also known as eMDCII, MDC-Ls and TECADAM, was first described in lymphocytes, also in Thymic Endothelial Cells (TECADAM), as well as in the epididymus. Later works describe two forms of ADAM28: ADAM28-S and ADAM28-L (short and long forms). The short form is a soluble, alternatively spliced form lacking the transmembrane and cytoplasmic domains. A member of the metalloproteinase family containing disintegrin-like domains (ADAMs) the functions of ADAM28 is still poorly understood. Other ADAMs family members (ADAM10, ADAM17) have been more thoroughly studied and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. ADAM28 may play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. It may be involved in sperm maturation.
• Synonyms: ADAM 28; eMDC II; eMDCII; MDC-L; MDCL
• Note: Suggested dilutions for western blot: 1:500

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane