APC Mouse Monoclonal Antibody [Clone ID: Ali 12-28]

CAT#: TA352977L

Mouse monoclonal Anti-APC Clone Ali 12-28

Specifications

Product Data

• Clone Name: Ali 12-28
• Recommended Dilution: ELISA ; IF ; IHC ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: N-terminal APC-MBP fusion protein
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 310
• Gene Name: adenomatous polyposis coli
• Database Link:
  NP_001120982
  Entrez Gene 324 Human
  UniProt ID P25054
• Background: The adenomatous polyposis coli (APC) tumour suppressor gene is mutated (often by deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and in over 80% of colorectal cancers. Ali 12-28 may be used for the detection of APC expression and APC mutations.
• Synonyms: BTPS2; DP2; DP2.5; DP3; GS; PPP1R46
• Note: Ali 12-28 detects both normal and mutant-truncated forms of the APC.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway