APC Mouse Monoclonal Antibody [Clone ID: c-APC 28.9]

CAT#: TA352978L

Mouse monoclonal Anti-hAPC Clone c-APC 28.9

Specifications

Product Data

• Clone Name: c-APC 28.9
• Recommended Dilution: IHC ; IF ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: human APC C-terminal fusion with MBP (maltose binding protein)
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: adenomatous polyposis coli
• Database Link:
  NP_001120982
  Entrez Gene 324 Human
  UniProt ID P25054
• Background: The adenomatous polyposis coli tumor suppressor gene is mutated (often deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and over 80% of colorectal cancers. C-APC 28.8 can be used for APC expression and detection of APC mutations. Clone c-APC 28.9 is useful for the detection of APC expression and detection of mutations. This antibody has been used routinely for Western blotting on colon cell line HCT116 extract which expresses full-length APC.
• Synonyms: BTPS2; DP2; DP2.5; DP3; GS; PPP1R46

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway