CD79A Mouse Monoclonal Antibody [Clone ID: HM57]
CAT#: TA353063L
Mouse monoclonal Anti-CD79a Clone HM57
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Specifications
Product Data | |
Clone Name | HM57 |
Recommended Dilution | FACS ; IHC ; IP ; WB |
Reactivities | Bovine, Chicken, Guinea Pig, Human, Mouse, Opossum, Primate, Rabbit, Rat, Pig, Horse |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Synthetic peptide of 14 amino acids representing residues 202-216 of the human mb-1 cDNA sequence. |
Formulation | PBS with 0.02% Sodium Azide |
Concentration | lot specific |
Purification | Purified by affinity chromatography. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | CD79a molecule |
Database Link | |
Background | The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections. |
Synonyms | IGA; MB-1 |
Note | Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well. |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | B cell receptor signaling pathway, Primary immunodeficiency |
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