CD79A Mouse Monoclonal Antibody [Clone ID: JCB117]

CAT#: TA353064L

Mouse monoclonal Anti-CD79a Clone JCB117

USD 1,140.00

9 Weeks*

Size
    • 500 ug

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Specifications

Product Data
Clone Name JCB117
Recommended Dilution IHC ; WB
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Synthetic peptide of 14 amino acids representing residues 202-216 of the human mb-1 cDNA sequence
Formulation PBS with 0.02% Sodium Azide
Concentration lot specific
Purification Purified by affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name CD79a molecule
Background The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections.
Synonyms IGA; MB-1
Note Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways B cell receptor signaling pathway, Primary immunodeficiency

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.