CD79B Mouse Monoclonal Antibody [Clone ID: B29/123]

CAT#: TA353066L

Mouse monoclonal Anti-CD79b Clone B29/123

Specifications

Product Data

• Clone Name: B29/123
• Recommended Dilution: IHC ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Synthetic peptide representing the c-terminus from residue 215 of the murine B29 polypeptide.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD79b molecule
• Database Link:
  NP_001035022
  Entrez Gene 974 Human
  UniProt ID P40259
• Background: The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling.
• Synonyms: AGM6; B29; IGB
• Note: Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: B cell receptor signaling pathway