B7-2 (CD86) Mouse Monoclonal Antibody [Clone ID: BU63]

CAT#: TA353067L

Mouse monoclonal Anti-CD86 Clone BU63

Specifications

Product Data

• Clone Name: BU63
• Recommended Dilution: FACS ; IHC ; IF ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: ARH 77 (B-lymphoblastoid cell line)
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD86 molecule
• Database Link:
  NP_001193853
  Entrez Gene 942 Human
  UniProt ID P42081
• Background: CD86 is a 70 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily of cell surface receptors. CD86 is expressed on resting monocytes and dendritic cells, activated T and Natural Killer cells, and is rapidly induced on the surface of activated B-cells, suggesting that it is a major CD28 ligand and may play an important role for the co-stimulation of T-cells in the primary immune response. CD86 is also expressed by malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.
• Synonyms: B7-2; B7.2; B70; CD28LG2; LAB72
• Note: Recommended for the inhibition of the mixed lymphocyte reaction (MLR) and the binding of soluble CTLA-4 (CD152)-mulg fusion protein to CD 86 (B7-2).

Reference Data

• Protein Families: Druggable Genome, Transcription Factors, Transmembrane
• Protein Pathways: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Graft-versus-host disease, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis