CD21 (CR2) Mouse Monoclonal Antibody [Clone ID: R4/23]

CAT#: TA353109L

Mouse monoclonal Anti-CD21L Clone R4/23

Specifications

Product Data

• Clone Name: R4/23
• Recommended Dilution: IHC ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: Cell lysate from a chronic lymphocytic leukemia patient.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: complement component 3d receptor 2
• Database Link:
  NP_001868
  Entrez Gene 1380 Human
  UniProt ID P20023
• Background: CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the â??Longâ?? isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
• Synonyms: C3DR; CD21; CR; CVID7; SLEB9
• Note: Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: B cell receptor signaling pathway, Complement and coagulation cascades, Hematopoietic cell lineage