Cytochrome P450 2A6 (CYP2A6) Mouse Monoclonal Antibody [Clone ID: RP1.2B4]

CAT#: TA353124L

Mouse monoclonal Anti-Cytochrome P450 2A6 Clone RP1.2B4

Product Images

Western Blot of recombinant CYP450s

Specifications

Product Data

• Clone Name: RP1.2B4
• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Human cytochrome P450
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cytochrome P450 family 2 subfamily A member 6
• Database Link:
  NP_000753
  Entrez Gene 1548 Human
  UniProt ID P11509
• Background: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]
• Synonyms: CPA6; CYP2A; CYP2A3; CYPIIA6; P450C2A; P450PB

Reference Data

• Protein Families: Druggable Genome, P450, Transmembrane
• Protein Pathways: Caffeine metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Retinol metabolism