EGLN2 Mouse Monoclonal Antibody [Clone ID: PHD112/G7]

CAT#: TA353156L

Mouse monoclonal Anti-PHD1 Clone PHD112/G7

Specifications

Product Data

• Clone Name: PHD112/G7
• Recommended Dilution: IHC ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: Full length recombinant human PHD1
• Formulation: PBS with 0.02% Sodium Azide
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 43.6
• Gene Name: egl-9 family hypoxia inducible factor 2
• Database Link:
  NP_444274
  Entrez Gene 112398 Human
  UniProt ID Q96KS0
• Background: PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.
• Synonyms: EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Pathways in cancer, Renal cell carcinoma