PHD3 (EGLN3) Mouse Monoclonal Antibody [Clone ID: EG188e/d5]

CAT#: TA353157L

Mouse monoclonal Anti-PHD3 Clone EG188e/d5

Specifications

Product Data

• Clone Name: EG188e/d5
• Recommended Dilution: IHC ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Residues 1-100 of human PHD3
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 27.3
• Gene Name: egl-9 family hypoxia inducible factor 3
• Database Link:
  NP_071356
  Entrez Gene 112399 Human
  UniProt ID Q9H6Z9
• Background: PHD3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, hydroxylates HIF-1 alpha at Pro-564, and also hydroxylates HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. It promotes cell death through a caspase-dependent mechanism
• Synonyms: HIFP4H3; HIFPH3; PHD3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Pathways in cancer, Renal cell carcinoma