Neutrophil Elastase (ELANE) Mouse Monoclonal Antibody [Clone ID: NP57]

CAT#: TA353159

Mouse monoclonal Anti-Neutrophil elastase Clone NP57

Specifications

Product Data

• Clone Name: NP57
• Recommended Dilution: IHC ; IHC ; IF ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Neutrophil granule proteins
• Formulation: PBS with 0.02% Sodium Azide
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: elastase, neutrophil expressed
• Database Link:
  NP_001963
  Entrez Gene 1991 Human
  UniProt ID P08246
• Background: Human Neutrophil Elastase (HNE) belongs to the chymotrypsin family of serine proteases able to solubilize fibrous elastin, an important extracellular matrix protein that has the unique property of elastic recoil, and plays a major structural function in lungs, arteries, skin and ligaments. HNE is primarily located in the azurophil granules of polymorphonuclear leucocytes, but has also been detected in nuclear membrane, Golgi complex, ER and the mitochondria of these cells. The enzyme is involved in the tissue destruction and inflammation and implicated in numerous diseases, including emphysema, chronic obstructive pulmonary disease, cystic fibrosis, ischemic-reperfusion injury and rheumatoid arthritis.
• Synonyms: ELA2; GE; HLE; HNE; NE; PMN-E; SCN1
• Note: This cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well.

Reference Data

• Protein Families: Protease, Transmembrane
• Protein Pathways: Systemic lupus erythematosus