HIF 2 alpha (EPAS1) Mouse Monoclonal Antibody [Clone ID: EP190B]

CAT#: TA353165L

Mouse monoclonal Anti-HIF2A Clone EP190b

Specifications

Product Data

• Clone Name: EP190B
• Recommended Dilution: ELISA ; IHC ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: GST-human EPAS-1 (HIF2A) amino acids 535-631 fusion protein
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: endothelial PAS domain protein 1
• Database Link:
  NP_001421
  Entrez Gene 2034 Human
  UniProt ID Q99814
• Background: Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF2A is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF1A has been observed in varying subsets of tumour cells from various solid tumours. HIF2A is also a potent activator of the tie2 gene, which is known to be selectively expressed in endothelial cells.
• Synonyms: bHLHe73; ECYT4; HIF2A; HLF; MOP2; PASD2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Renal cell carcinoma