CD49b (ITGA2) Mouse Monoclonal Antibody [Clone ID: 16B4]

CAT#: TA353247L

Mouse monoclonal Anti-CD49b Clone 16B4

Specifications

Product Data

• Clone Name: 16B4
• Recommended Dilution: ELISA ; FACS ; IHC ; IF ; IP
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified human beta 1 preparation from HT1080 fibrosarcoma cell extract.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha 2
• Database Link:
  NP_002194
  Entrez Gene 3673 Human
  UniProt ID P17301
• Background: CD49b is an integrin alpha subunit which makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling.
• Synonyms: BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2
• Note: 16B4 can be used to immunoprecipitate a non-reducible alpha subunit from I(125) surface labelled Human cell line extract. It is specific to the alpha 2 subunit by relative expression of antigen on various cell lines by FACS, and its recognition of affinity purified alpha 2 beta 1 in dot blots.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer