CD49b (ITGA2) Mouse Monoclonal Antibody [Clone ID: 31H4]

CAT#: TA353248L

Mouse monoclonal Anti-CD49b Clone 31H4

Specifications

Product Data

• Clone Name: 31H4
• Recommended Dilution: ELISA ; FACS ; IP
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified human b1 integrin preparation from HT1080 fibrosarcoma cell extract.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha 2
• Database Link:
  NP_002194
  Entrez Gene 3673 Human
  UniProt ID P17301
• Background: CD49b also known as integrin alpha-2, VLA-2 subunit alpha or collogen receptor. CD49b is a 1181 amino acid ¦130 kDa single pass type-1 transmembrane glycoprotein which forms a heterodimer with integrin beta-1 and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia.
• Synonyms: BR; CD49B; GPIa; HPA-5; VLA-2; VLAA2
• Note: Does not cross-react with Rat.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer