CD11b (ITGAM) Mouse Monoclonal Antibody [Clone ID: ICRF44]

CAT#: TA353260L

Mouse monoclonal Anti-Integrin aM Clone ICRF44

Specifications

Product Data

• Clone Name: ICRF44
• Recommended Dilution: FACS ; IHC ; IP ; WB
• Reactivities: Human, Primate
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Rheumatoid synovial cells and human monocytes.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 160
• Gene Name: integrin subunit alpha M
• Database Link:
  NP_000623
  Entrez Gene 3684 Human
  UniProt ID P11215
• Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha M is found in neutrophils, monocytes and NK cells. Patients lacking integrin aM molecules have immune deficiency symptoms and commonly subject to bacterial and fungal infections. ICRF 44 blocks some functions of Mac-1.
• Synonyms: CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Leukocyte transendothelial migration, Regulation of actin cytoskeleton