CD11c (ITGAX) Mouse Monoclonal Antibody [Clone ID: 3.9]

CAT#: TA353263L

Mouse monoclonal Anti-Integrin aX Clone 3.9

Specifications

Product Data

• Clone Name: 3.9
• Recommended Dilution: FACS ; IHC ; IP ; Functional
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Rheumatoid synovial fluid cells and fibronectin purified human monocytes
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 150
• Gene Name: integrin subunit alpha X
• Database Link:
  NP_000878
  Entrez Gene 3687 Human
  UniProt ID P20702
• Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha X is found on hairy cell leukaemias, malignant histiocytes, on tissue macrophages, monocytes, activated neutrophils and some T-cell clones.
• Synonyms: CD11C; SLEB6
• Note: Shown to inhibit adhesion in Jawhara et al., 2012.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Regulation of actin cytoskeleton