CD61 (ITGB3) Mouse Monoclonal Antibody [Clone ID: MHF4]

CAT#: TA353274L

Mouse monoclonal Anti-Integrin b3 Clone MHF4

Specifications

Product Data

• Clone Name: MHF4
• Recommended Dilution: FACS ; IHC ; IF ; IP
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: A bone cell suspension containing osteoclasts, osteoblasts and bone marrow cells obtained from the long bones of newborn Sprague Dawley rats.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 118/100
• Gene Name: integrin subunit beta 3
• Database Link:
  NP_000203
  Entrez Gene 29302 RatEntrez Gene 3690 Human
  UniProt ID P05106
• Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin b3 is expressed in osteoclasts, megacaryocytes and platelets. MHF4 may be used to identify osteoclasts in tissue sections and bone cell suspensions. The MHF4 epitope is different to the F11 epitope.
• Synonyms: BDPLT2; BDPLT16; CD61; GP3A; GPIIIa; GT
• Note: A heterodimeric molecule with a characteristic shift in apparent molecular mass on reduction (137/78 kDa nonreduced; 118/100 kDa reduced).

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton