MMP3 Mouse Monoclonal Antibody [Clone ID: 1B4]

CAT#: TA353337L

Mouse monoclonal Anti-MMP3 Clone 1B4

Product Images

400 ng samples of recombinant human pro-enzyme (lane 1 = MMP-1; lane 2 = MMP-3; lane 3 = MMP-2; lane 4 = MMP-9) were subjected to SDS-PAGE, transferred to PVDF membrane and detected by immunoblotting with Mab 1B4 specific for MMP-3.

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  IHC staining of human oesophageal adenocarcinoma.

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  Tissues tested for MMP-3 expresstion using MAb 1B4.

Specifications

Product Data

• Clone Name: 1B4
• Applications: IHC, WB
• Recommended Dilution: ELISA ; IHC ; IF ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH
• Formulation: PBS with 0.02% Sodium Azide
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: matrix metallopeptidase 3
• Database Link:
  NP_002413
  Entrez Gene 4314 Human
  UniProt ID P08254
• Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
• Synonyms: CHDS6; MMP-3; SL-1; STMY; STMY1; STR1
• Note: Western blot: not reactive with MMP-1, MMP-2, MMP-9

Reference Data

• Protein Families: Druggable Genome, Protease