PCNA Mouse Monoclonal Antibody [Clone ID: PC10]

CAT#: TA353373L

Mouse monoclonal Anti-PCNA Clone PC10

Specifications

Product Data

• Clone Name: PC10
• Recommended Dilution: FACS ; IHC ; IF ; IP ; WB
• Reactivities: Human, Insect, Saccharomyces pombe
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Protein A-PCNA fusion obtained from pC2T.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 36
• Gene Name: proliferating cell nuclear antigen
• Database Link:
  NP_002583
  Entrez Gene 5111 Human
  UniProt ID P12004
• Background: PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is potentially a therapeutic target in cancer therapy and a useful marker for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). This antibody can be used for grading of different neoplasms, e.g. astrocytoma. It can be of diagnostic and prognostic value.
• Synonyms: ATLD2
• Note: Recommended for use on formalin-fixed paraffin embedded sections. NEUTRAL ELUTE ONLY.

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair