CD45 (PTPRC) Mouse Monoclonal Antibody [Clone ID: HLe-1(2D1)]

CAT#: TA353404L

Mouse monoclonal Anti-PTPRC Clone HLe-1(2D1)

Specifications

Product Data

• Clone Name: HLe-1(2D1)
• Recommended Dilution: FACS ; IHC ; IF
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human peripheral blood mononuclear cells.
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 180-220
• Gene Name: protein tyrosine phosphatase, receptor type C
• Database Link:
  NP_002829
  Entrez Gene 5788 Human
  UniProt ID P08575
• Background: PTPRC is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). Hle-1 can be used in a panel of several monoclonal antibodies to characterise tumours.
• Synonyms: B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
• Note: The antibody clone name was called "Hle-1" in Cobbold et al., 1986. Proceedings of the 3rd International Workshop and Conference; Oxford, England. Oxford University Press; 1987. p. 788-803.

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway