beta 1 Spectrin (SPTB) Mouse Monoclonal Antibody [Clone ID: RG/26]

CAT#: TA353474L

Mouse monoclonal Anti-Spectrin Clone RG/26

Specifications

Product Data

• Clone Name: RG/26
• Recommended Dilution: IHC ; IF ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Red cell membranes
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: spectrin beta, erythrocytic
• Database Link:
  NP_000338
  Entrez Gene 6710 Human
  UniProt ID P11277
• Background: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.
• Synonyms: EL3; HS2; HSPTB1; SPH2
• Note: Please note this cell line has not been weaned out of HAT. Ultroser G can be used at 1% if the cells are not growing well.

Reference Data

• Protein Families: Druggable Genome