TIGAR Mouse Monoclonal Antibody [Clone ID: 9C10]

CAT#: TA353508L

Mouse monoclonal Anti-TIGAR Clone 9C10

Specifications

Product Data

• Clone Name: 9C10
• Recommended Dilution: ChIP ; IP ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: A 15-amino acid peptide corresponding to the exon COOH-terminal region of human TIGAR protein (CMNLQDHLNGLTETR).
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 30
• Gene Name: TP53 induced glycolysis regulatory phosphatase
• Database Link:
  NP_065108
  Entrez Gene 57103 Human
  UniProt ID Q9NQ88
• Background: TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis. TIGAR functions to lower fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis, and an overall decrease in intracellular reactive oxygen species (ROS) levels, correlating with a decreased sensitivity to apoptosis.
• Synonyms: C12orf5; FR2BP
• Note: Suggested dilution of 1:5000