TIGAR Mouse Monoclonal Antibody [Clone ID: 9C10]
CAT#: TA353508L
Mouse monoclonal Anti-TIGAR Clone 9C10
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Specifications
Product Data | |
Clone Name | 9C10 |
Recommended Dilution | ChIP ; IP ; WB |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | A 15-amino acid peptide corresponding to the exon COOH-terminal region of human TIGAR protein (CMNLQDHLNGLTETR). |
Concentration | lot specific |
Purification | Purified by affinity chromatography. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 30 |
Gene Name | TP53 induced glycolysis regulatory phosphatase |
Database Link | |
Background | TIGAR (TP53 induced glycolysis and apoptosis regulator) is a novel p53-inducible gene, that shows similarity to the bisphosphatase domain of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, the main regulator of glycolysis. TIGAR functions to lower fructose-2,6-bisphosphate levels in cells, resulting in an inhibition of glycolysis, and an overall decrease in intracellular reactive oxygen species (ROS) levels, correlating with a decreased sensitivity to apoptosis. |
Synonyms | C12orf5; FR2BP |
Note | Suggested dilution of 1:5000 |
Reference Data |
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