TIMP1 Mouse Monoclonal Antibody [Clone ID: 2A5]

CAT#: TA353510L

Mouse monoclonal Anti-TIMP1 Clone 2A5

USD 1,140.00

9 Weeks*

Size
    • 500 ug

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Specifications

Product Data
Clone Name 2A5
Applications IHC, WB
Recommended Dilution ELISA ; IHC ; WB
Reactivities Human
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Ovalbumin-conjugated synthetic peptide; FQALGDAADIR
Concentration lot specific
Purification Purified by affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name TIMP metallopeptidase inhibitor 1
Background Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis. Expression of TIMP1 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.
Synonyms CLGI; EPA; EPO; HCI; TIMP; TIMP-1
Note IHC: A recommended dilution of 1/8. Recommended pretreatment of antigen retrieval: microwave for 7 minutes at 950W in 0.01M sodium citrate buffer, pH 6.0.
Reference Data
Protein Families Druggable Genome, Secreted Protein

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.