TIMP2 Mouse Monoclonal Antibody [Clone ID: 3A4]

CAT#: TA353511L

Mouse monoclonal Anti-TIMP2 Clone 3A4

Product Images

400ng samples of recombinant human pro-enzyme (lane 1= TIMP-1; lane 2 = TIMP-2) were subjected to SDS-PAGE, transferred to PVDF membrane, and detected with mAb 3A4, specific for TIMP-2.

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  IHC staining of human colon tissues.

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  Tissues tested for TIMP-2 expresstion using MAb 3A4.

Specifications

Product Data

• Clone Name: 3A4
• Applications: IHC, WB
• Recommended Dilution: ELISA ; IHC ; WB
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2b, kappa
• Clonality: Monoclonal
• Immunogen: Ovalbumin-conjugated synthetic peptide; DSGNDIYGNPI
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TIMP metallopeptidase inhibitor 2
• Database Link:
  NP_003246
  Entrez Gene 21858 MouseEntrez Gene 29543 RatEntrez Gene 7077 Human
  UniProt ID P16035
• Background: Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumour invasion and metastasis. Expression of TIMP2 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.
• Synonyms: CSC-21K; DDC8
• Note: (i) no cross-reactivity with TIMP-1 in immunoblot, (ii) staining in antigen-positive wax-imbedded tissues

Reference Data

• Protein Families: Druggable Genome, Secreted Protein