p53 (TP53) Mouse Monoclonal Antibody [Clone ID: Pab 1801]

CAT#: TA353526L

Mouse monoclonal Anti-p53 Clone Pab 1801

Specifications

Product Data

• Clone Name: Pab 1801
• Recommended Dilution: ChIP ; ELISA ; FACS ; IHC ; IP ; Radio Immuno Assay ; WB
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified p53-b-galactosidase fusion proteins
• Formulation: PBS with 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 53
• Gene Name: tumor protein p53
• Database Link:
  NP_000537
  Entrez Gene 7157 Human
  UniProt ID P04637
• Background: p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. PAb 1801 can be used for the specific detection of human p53 that is synthesised in the presence of p53 from other species.
• Synonyms: BCC7; LFS1; P53; TRP53
• Note: PAb 1801 may be used for the specific detection of human p53 which is synthesised in the presence of p53 from other species and is suitable for immunohistochemistry using paraffin embedded samples with pepsin treatment. pAb1801,which recognizes an epitope between amino acids 32 and 79 of both wild-type and mutant p53 (from PMID:12692844)

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Apoptosis, Basal cell carcinoma, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Glioma, Huntington's disease, MAPK signaling pathway, Melanoma, Neurotrophin signaling pathway, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Wnt signaling pathway