Von Willebrand Factor (VWF) Mouse Monoclonal Antibody [Clone ID: RFF-VIII:R/1]

CAT#: TA353545L

Mouse monoclonal Anti-vWF Clone RFF-VIII:R/1

Specifications

Product Data

• Clone Name: RFF-VIII:R/1
• Recommended Dilution: ELISA ; FACS ; IF ; Functional ; Radio Immuno Assay ; WB
• Reactivities: Primate
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: Purified human Factor VIII-VWF complex
• Concentration: lot specific
• Purification: Purified by affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: von Willebrand factor
• Database Link:
  NP_000543
  Entrez Gene 7450 Human
  UniProt ID P04275
• Background: The monoclonal antibody RFF-VIII:R/2 specifically binds to human factor VIII related antigen (VIII:RAg) in plasma and in vascular endothelial cells but has no reactivity with factor VIII procoagulant antigen (VIII:cAg). This antibody is a potent inhibitor of von Willebrand factor activity in that it can totally neutralise risocetin-induced aggregation of platelet rich plasma and inhibit platelet adhesion at high flow rates. RFF-VIII:R/2 can be used in a one-stage, fluid phase immunoradiometric assay that can detect VIII:RAg. This monoclonal antibody binds to human von Willebrand factor (VW) and inhibits it's binding to platelets. Very similar in characteristics to RFF-VIII:R/1.
• Synonyms: F8VWF; VWD
• Note: IHC - Paraffin (1:50 - 1:200)

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Complement and coagulation cascades, ECM-receptor interaction, Focal adhesion