XPC Rabbit Polyclonal Antibody

CAT#: TA353548L

Rabbit polyclonal anti-Xeroderma Pigmentosum Group C (XPC) antibody

Specifications

Product Data

• Recommended Dilution: IF ; WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Xeroderma Pigmentosum Group C (XPC)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: XPC complex subunit, DNA damage recognition and repair factor
• Database Link:
  NP_001139241
  Entrez Gene 7508 Human
  UniProt ID Q01831
• Background: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity.
• Synonyms: RAD4; XP3; XPCC
• Note: This antibody is not available for licence, please refer to supplier information to find a source of the antibody.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Nucleotide excision repair