14-3-3 zeta (YWHAZ) Rabbit Polyclonal Antibody

CAT#: TA354166

Rabbit anti 14-3-3 zeta Polyclonal Antibody

Specifications

Product Data

• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the internal sequence (134-149aa) of human zeta.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 30 kDa
• Gene Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
• Database Link:
  NP_001129171
  Entrez Gene 22631 MouseEntrez Gene 25578 RatEntrez Gene 7534 Human
  UniProt ID P63104
• Background: The 14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14.3.3 zeta protein is a ubiquitous and abundant in brain. 14.3.3 zeta binds primarily to Raf noncatalytic sequences without inhibiting the Ras-Raf association or Raf-catalyzed MEK phosphorylation, thus it might act as a sweeper of misfolded protein by facilitating the formation of aggregates (inclusion bodies). Hence, 14-3-3 zeta may be considered as an auxiliary therapeutic tool in the protein aggregation disorders.
• Synonyms: 14-3-3-zeta; HEL-S-3; HEL4; KCIP-1; YWHAD

Reference Data

• Protein Pathways: Cell cycle, Neurotrophin signaling pathway, Oocyte meiosis, Pathogenic Escherichia coli infection