Sumo 2 (SUMO2) Rabbit Polyclonal Antibody

CAT#: TA354223

Rabbit anti SUMO-2/Sentrin-2 Polyclonal Antibody

Product Images

WB: The cell lysate derived from Hela cells was immunoblotted by the Rabbit anti-Sentrin-2 antibody at 1:500. An immunoreactive band is observed at ~10 kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA Not tested IP 2-5 µg/ml IHC 2-10 µg/ml FC Not tested
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide derived from C-terminus of human Sentrin-2 protein. This sequence is identical to human, mouse and rat.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 10 kDa
• Gene Name: small ubiquitin-like modifier 2
• Database Link:
  NP_001005849
  Entrez Gene 6613 Human
  UniProt ID P61956
• Background: Sentrin-2 also known as SUMO-2 is a 95-amino acids peptide that has high homologous to Sentrin-1/SUMO-1. This novel ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
• Synonyms: HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3

Reference Data

• Protein Families: Druggable Genome