Sumo 2 (SUMO2) Rabbit Polyclonal Antibody

CAT#: TA354223

Rabbit anti SUMO-2/Sentrin-2 Polyclonal Antibody


USD 355.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications WB
Recommended Dilution WB 0.1-1 µg/ml ELISA Not tested IP 2-5 µg/ml IHC 2-10 µg/ml FC Not tested
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide derived from C-terminus of human Sentrin-2 protein. This sequence is identical to human, mouse and rat.
Formulation This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 10 kDa
Gene Name small ubiquitin-like modifier 2
Background Sentrin-2 also known as SUMO-2 is a 95-amino acids peptide that has high homologous to Sentrin-1/SUMO-1. This novel ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
Synonyms HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3
Reference Data
Protein Families Druggable Genome

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.