GABA B Receptor 1 (GABBR1) Rabbit Polyclonal Antibody

CAT#: TA354237

Rabbit anti GABA Receptor 1 Polyclonal Antibody

Product Images

WB: The brain tissue lysate derived from mouse (lane 1) and rat brain (lane 2) was immunoblotted by the Rabbit anti-GABA receptor 1 at 1:500. A major immunoreactive band is observed at ~100 kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide derived from N-term of human GABA receptor 1 protein. This sequence is identical to human and rat.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 100 kDa
• Gene Name: gamma-aminobutyric acid type B receptor subunit 1
• Database Link:
  NP_001461
  Entrez Gene 54393 MouseEntrez Gene 81657 RatEntrez Gene 2550 Human
  UniProt ID Q9UBS5
• Background: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. It acts at GABA receptors to produce fast synaptic inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The overexpression of one particular gene encoding for G-protein-activated inward rectifying potassium type 2 (GIRK2) channel subunit and its coupling to GABA(B) receptors may contribute to a range of mental and functional disabilities
• Synonyms: GABABR1; GABBR1-3; GB1; GPRC3A

Reference Data

• Protein Families: Druggable Genome, GPCR, Secreted Protein, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction