CD14 Rabbit Polyclonal Antibody

CAT#: TA354268

Rabbit anti CD14 Polyclonal Antibody

Specifications

Product Data

• Recommended Dilution: WB 0.1-1 µg/ml ELISA N/A IP N/A IHC 2-10 µg/ml FC Not tested
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein encoding aa 1-201 of human CD14
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 55 kDa
• Gene Name: CD14 molecule
• Database Link:
  NP_000582
  Entrez Gene 929 Human
  UniProt ID P08571
• Background: CD14, also known lipopolysaccharide (LPS) receptor, is a 55 kDa glycosylphosphatidylinositol (GPI)-linked membrane glycoprotein. It is expressed at high levels on monocytes and macrophage, and at lower levels on the surface of granulocytes and neutrophils. Some dendritic cell populations such as interfollicular dendritic cells, reticular dendritic cells, and Langerhans cells have also been reported to express CD14. CD14 is anchored to cells by linkage to GPI and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation. CD14 is involved in the clearance of gram-negative pathogens and in the up-regulation of adhesion molecules and cytokines expression in monocytes and neutrophils.
• Synonyms: CD14 antigen; CD14 molecule; monocyte differentiation antigen CD14

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway