CD45 (PTPRC) Rabbit Polyclonal Antibody
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Specifications
Product Data | |
Recommended Dilution | WB 0.1-1 µg/ml ELISA N/A IP N/A IHC 2-10 µg/ml FC 5-10 µg/ml |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein encoding aa 1119-1304 of human CD45. |
Formulation | This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer. |
Purification | The Rabbit IgG is purified by Epitope Affinity Purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 220, 205, 190, 180 kDa |
Gene Name | protein tyrosine phosphatase, receptor type C |
Database Link | |
Background | CD45 leucocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals. CD45 plays an essential role in lymphocyte activation. |
Synonyms | B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200 |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane |
Protein Pathways | Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway |
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