CD4 Rabbit Polyclonal Antibody

CAT#: TA354328

Rabbit anti CD4 Polyclonal Antibody

Specifications

Product Data

• Recommended Dilution: WB 0.1-1 µg/ml ELISA N/A IP 2-5 µg/ml IHC 2-10 µg/ml FC Not tested
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to internal region of human CD4 protein
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa
• Gene Name: CD4 molecule
• Database Link:
  NP_000607
  Entrez Gene 920 Human
  UniProt ID P01730
• Background: CD4, a single-pass type I transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is an accessory protein for MHC class-II antigen/T-cell receptor interaction, and may regulate T-cell activation, induce the aggregation of lipid rafts. Upon HIV-1 binding to the cell membrane, CD4 interacts with HIV-1 envelope polyprotein gp160 and protein Vpu with presence of HIV-1 gp120.
• Synonyms: CD4mut

Reference Data

• Protein Families: Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transmembrane
• Protein Pathways: Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway