p16INK4A (CDKN2A) Rabbit Polyclonal Antibody

CAT#: TA354353

Rabbit anti p16INK4a (CT) Polyclonal Antibody

Product Images

WB: The cell lysate derived from HT-29 was immunoprobed by Rabbit anti-p16INK4a at 1:500. An immunoreactive band is observed around ~18 kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the C-terminus of human p16INK4a protein.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~16-18 kDa
• Gene Name: cyclin-dependent kinase inhibitor 2A
• Database Link:
  NP_000068
  Entrez Gene 1029 Human
  UniProt ID Q8N726
• Background: The INK4 (inhibitor of cyclin-dependent kinase 4) family consists of four tumor-suppressor proteins: p15(INK4B), p16(INK4A), p18(INK4C), and p19(INK4D). While their sequences and structures are highly homologous, they show appreciable differences in conformational flexibility, stability, and aggregation tendency. p16 (INK4a, CDKN2A, cyclin dependent kinase inhibitor 2A) is a tumor suppressor gene that inhibits cdk4 and cdk6 which phosphorylate the Rb protein. P16INK4a overexpression has been demonstrated in cervical cancers as a result of functional inactivation of pRb Thus, this antibody can be an important marker for dysplastic squamous and glandular cells of the cervix.
• Synonyms: ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer