Caspase 10 (CASP10) Rabbit Polyclonal Antibody

CAT#: TA354379

Rabbit anti Caspase 10 Polyclonal Antibody

Product Images

WB: The cell lysate derived from Jurkat was immunoblotted by the Rabbit anti-Caspase-10 antibody at 1:500. Multiple immunoreactive bands are observed around 59-17 kDa.

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  IHC: Human liver carcinoma stained with anti-Caspase-10 antibody at 1:50 for 30 min, RT. (Staining of formalin-fixed tissues requires boiling tissue section in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to C-term of human Caspase 10. This sequence is identical to mouse and rat.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 59 kDa for precursor; 23,17 kDa
• Gene Name: caspase 10
• Database Link:
  NP_001193453
  Entrez Gene 843 Human
  UniProt ID Q92851
• Background: A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7, caspase-9, and caspase-10. Ced-3 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
• Synonyms: ALPS2; FLICE2; MCH4

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Apoptosis, RIG-I-like receptor signaling pathway