BCAR3 Rabbit Polyclonal Antibody

CAT#: TA354459

Rabbit anti BCAR3 Polyclonal Antibody

Product Images

WB: The cell lysate derived from FBS-replenished Hela was immunoblotted by the following antibodies at 1:500: Lane 1:Rabbit anti-BCAR3 (pT130) Lane 2:Rabbit anti-BCAR3 (Paired T130) Lane 3:Rabbit anti-BCAR3 Lane 4: Negative control (Rabbit IgG). An immunoreactive band is observed at ~93 kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide derived from C-terminus of human BCAR3 protein. This sequence is identical to human, rat, mouse, canis and bovine.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 93 kDa
• Gene Name: breast cancer anti-estrogen resistance 3
• Database Link:
  NP_001248337
  Entrez Gene 29815 MouseEntrez Gene 310838 RatEntrez Gene 8412 Human
  UniProt ID O75815
• Background: Breast cancer anti-estrogen resistance 3 (BCAR3) is a also known as AND-34/BCAR3/NSP2 (BCAR3). Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. BCAR3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48
• Synonyms: NSP2; SH2D3B

Reference Data

• Protein Families: Druggable Genome