CREB1 Rabbit Polyclonal Antibody

CAT#: TA354480

Rabbit anti CREB(pS133) Polyclonal Antibody

Product Images

WB: The tissue lysate derived from ischemia rat brain was immunoprecipitated by Rabbit anti-CREB antibody, then immuno-blotted by the Rabbit anti-phospho-CREB (pS133) antibody at 1:500 (lane 1), Lane 2: negative control.

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  DB: 1 ug peptide was blot onto NC membrane A:CREB (pS133) B: CREB (non phosphorylated) C: Non-related Phosphopeptide) Followed by rabbit antibodies incubation at a 1:1000 dilution: 1: Rabbit anti-CREB (pS188) 2: Rabbit anti-CREB (Paired S133)

Specifications

Product Data

• Applications: Dot, WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the epitope of RPSYR with a single phosphorylation site Ser133.
• Formulation: This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 40 kDa
• Gene Name: cAMP responsive element binding protein 1
• Database Link:
  NP_004370
  Entrez Gene 1385 Human
  UniProt ID P16220
• Background: CREB is a bZIP transcription factor that binds the cAMP response element (CRE) and activates target genes. It is involved in many extracellular signals resulting in regulation of a variety of cellular responses. Phosphorylation of CREB at Ser133 by various kinases, such as PKA, PKC, CaM kinase II and IV, is necessary for CREB signaling.
• Synonyms: CREB

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer