GSK3 alpha (GSK3A) Rabbit Polyclonal Antibody

CAT#: TA354485

Rabbit anti GSK3a(pS21) Polyclonal Antibody

Product Images

WB: The 3T3 cell lysate derived from conditioned culture medium was resolved onto 10% SDSPAGE, transferred onto NC membrane, and followed by an immunoblotting with Rabbit anti-GSK-3 alpha (pS21) antibody at 1:500 (lane 1). Lane 2 was pre-incubated with immunizing peptide

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide surrounding to the epitope -RTSSFA- with a phosphorylation site at Ser21 of human GSK3-alpha protein. This sequence is identical among human, mouse and rat.
• Formulation: This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 52 kDa
• Gene Name: glycogen synthase kinase 3 alpha
• Database Link:
  NP_063937
  Entrez Gene 50686 RatEntrez Gene 606496 MouseEntrez Gene 2931 Human
  UniProt ID P49840
• Background: Glycogen Synthase Kinase-3 has two isoforms, GSK-3a and GSK3β. GSK3 is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase as well as the regulation in Wnt signal pathway. GSK-3 alpha reduces the substrates beta-catenin and tau to imply an important role in Wnt signaling and tauopathies such as Alzheimer’s disease..
• Synonyms: DKFZp686D0638

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway