PSAP Rabbit Polyclonal Antibody

CAT#: TA354500

Rabbit anti SAPOSIN(PSAP) Polyclonal Antibody

Product Images

WB: The whole cell lysate derived from human hepatoma HepG2 was immunoblotted Rabbit anti-Saposin at 1:500.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to internal sequence (within 300-360aa) of human Saposin.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 70 kDa
• Gene Name: prosaposin
• Database Link:
  NP_001035930
  Entrez Gene 5660 Human
  UniProt ID P07602
• Background: The Saposin family includes four structurally related proteins, saposin A, B, C, and D which are ~80 aa small acidic acitvator proteins with specificities for glycosphingolipid (GSL) hydrolases. They are derived from a single precursor, prosaposin. In both humans and mice, prosaposin/saposin deficiencies lead to severe neurological deficits. Saposins are processed from prosaposin in the late endosome and lysosome, and their stability is maintained by three disulfide bridges. The post-modified prosoposin is an ~70 kDa form which subsequently undergoes partial proteolysis to produce saposin A, B, C, and D, each proteins are between 12-14 kDa in mass.
• Synonyms: GLBA; SAP1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysosome