Plectin (PLEC) Rabbit Polyclonal Antibody

CAT#: TA354534

Rabbit anti Plectin Polyclonal Antibody

Specifications

Product Data

• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the C-term portion of human Plectin. This sequence is identical to rat, mouse and human origins.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~500 kDa
• Gene Name: plectin
• Database Link:
  NP_000436
  Entrez Gene 18810 MouseEntrez Gene 64204 RatEntrez Gene 5339 Human
  UniProt ID Q15149
• Background: Plectin is a cytoskeleton linker protein expressed in a variety of tissues including skin, muscle, and nerves. Plectin can bind to several molecules (intermediate filaments) that make up the cytoskeleton. Mutations in its gene are associated with epidermolysis bullosa simplex with late-onset muscular dystrophy. In certain skin cells, this protein is an essential part of hemidesmosomes, which attach the network of intermediate filaments to the cell membrane. It is also a component of desmosomes, which form junctions between neighboring cells. As part of these structures, plectin plays a critical role in anchoring the outer layer of the skin (the epidermis) to underlying layers. Mutations in the PLEC1 gene also cause at least two other forms of epidermolysis bullosa
• Synonyms: EBS1; EBSO; HD1; LGMD2Q; PCN; PLEC1; PLEC1b; PLTN

Reference Data

• Protein Families: Druggable Genome