Tenascin C (TNC) Rabbit Polyclonal Antibody

CAT#: TA354535

Rabbit anti Tenascin C Polyclonal Antibody


USD 350.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide corresponding to the internal segment of Tenascin C protein. This sequence is identical among human, rat and mouse.
Formulation This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size ~240 kDa
Gene Name tenascin C
Background Tenascin-C (TN-C) is an extracellular matrix glycoprotein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues. It is usually derived from myofibroblasts in the cancer microenvironment. It has diverse functions, including weakening of cell adhesion, up-regulating the expression and activity of matrix metalloproteinases, modulating inflammatory responses, promoting recruitment of myofibroblasts, and enhancing fibrosis. TN-C could exert both harmful and protective effects and might be a therapeutic target as a key molecule in the control of the balance of beneficial and undesirable cellular responses during tissue remodeling. Cancer cell-specific TNC is a novel indicator of poor prognosis.
Synonyms 150-225; DFNA56; GMEM; GP; HXB; JI; TN; TN-C
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways ECM-receptor interaction, Focal adhesion

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.