LRRK2 Rabbit Polyclonal Antibody

CAT#: TA354712

Rabbit anti LRRK2 Polyclonal Antibody

Product Images

WB: The cell lysate derived from 3T3 was immunoprobed by Rabbit anti-LRRK2 at 1:500. An immunoreactive band is observed around ~285 kDa (1). This band is abolished by pre-incubation with immunizing peptide (2).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to C-terminus of human LRRK2.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 285 kDa
• Gene Name: leucine-rich repeat kinase 2
• Database Link:
  NP_940980
  Entrez Gene 120892 Human
  UniProt ID Q5S007
• Background: The leucine-rich repeat kinase family (LRKK) proteins are consists of an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40. Various genes and loci (a-synuclein/PARK1 and 4, parkin/PARK2, UCH-L1/PARK5, PINK1/PARK6, DJ-1/PARK7, LRRK2/PARK8, synphilin-1 and NR4A2) are associated to Parkinson’s Disease (PD). LRRK2 may play an important role as a therapeutic target for treatment of PD (5).
• Synonyms: AURA17; DARDARIN; PARK8; RIPK7; ROCO2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Parkinson's disease