Androgen Receptor (AR) Rabbit Polyclonal Antibody

CAT#: TA354726

Rabbit anti Androgen Receptor (AR) (pS210) Polyclonal Antibody

Product Images

WB: 5 mg of the whole cell lysate derived from conditioned LNCaP were immunoprecipitated by 4 ug of Rabbit anti-AR (pSer210) (lane 1) or pre adsorbed by immunization peptide (lane 2) followed by rabbit anti-AR (NT) at 1:500.

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  DB: 1 ug peptide was blot onto NC membrane A: AR (pS210) B: AR (Nonphospho); were blotted at a 1:2000 dilution by: 1: Rabbit anti-AR (pS210), ;

Specifications

Product Data

• Applications: Dot, WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide surrounding the epitope –EASGA- with a single phosphorylation site Ser210. This sequence is identical among human, rat, mouse, dog.
• Formulation: This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 110 kDa
• Gene Name: androgen receptor
• Database Link:
  NP_000035
  Entrez Gene 11835 MouseEntrez Gene 24208 RatEntrez Gene 367 Human
  UniProt ID P10275
• Background: The androgen receptor (AR), a member of nuclear receptor family, is essential for the growth of prostate cancer cells. The phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. It’s been reported the signal pathway of the PI3K/AKT, Src to be responsible for phosphorylation of AR at Ser213/210 and Ser81. The abnormal activation of AR is observed in many diseases, such as prostate cancer.
• Synonyms: AIS; AR8; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Oocyte meiosis, Pathways in cancer, Prostate cancer