H3FA (HIST1H3A) Rabbit Polyclonal Antibody

CAT#: TA354739

Rabbit anti Histone H3 (pSer10) Polyclonal Antibody


USD 355.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide containing -QTARKSTGGKA-with phosphorylated serine 10 of human Histone H3.
Formulation This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 17 kDa
Gene Name histone cluster 1, H3a
Background Histones are basic nuclear proteins that together with DNA make up the nucleosome structure in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). Histone H1 and the N-terminal tail of H3 have key roles in the folding and inter-association of the chromatin fiber. Histone phosphorylation influences transcription, chromoscome condensation, DNA repair and apoptosis. The phosphorylation of Histone H3 at Serine 10 is linked to gene activation, prevents methylation at Lys9 but facilitates acetylation of H3 and H4. pSer10 is also associated with c-fos and c-myc genes.
Synonyms A; H3; H3FA
Reference Data
Protein Pathways Systemic lupus erythematosus

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.