MMP13 Rabbit Polyclonal Antibody

CAT#: TA354742

Rabbit anti MMP-13 Polyclonal Antibody

Product Images

WB: The protein derived from the SW1353 whole cell lysate was resolved onto 12% SDSPAGE, transferred to NC membrane, followed by an immunoblotting with Rabbit anti-MMP-13 at 1:1000.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the hinge of human MMP13 protein. This sequence is identical among the human, mouse and rat origins.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa, 48 kDa
• Gene Name: matrix metallopeptidase 13
• Database Link:
  NP_002418
  Entrez Gene 4322 Human
  UniProt ID P45452
• Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Unpaired specific MMPs by tissue inhibitor of MMPs (TIMPs) are related in the invasive tumor processes. Interstitial collagenase (MMP-1)(52 kDa), gelatinase A/type IV collagenase (MMP-2) (72 kDa), and gelatinase B/type V collagenase (MMP-9) (92 kDa) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis. Human collagenase-3 (MMP13) is a recently identified member of the matrix metalloproteinase (MMP) family that is expressed in breast carcinomas and in articular cartilage from arthritic patients. This protein is secreted as a 60 kDa proenzyme and active form of 48 kDa by cleavage.
• Synonyms: CLG3; MANDP1; MDST; MMP-13

Reference Data

• Protein Families: Druggable Genome, Protease