Fumarylacetoacetate hydrolase (FAH) Rabbit Polyclonal Antibody

CAT#: TA354752

Rabbit anti FAH (Fumarylacetoacetat Hydrolase) Polyclonal Antibody

Product Images

WB: The whole cell lysate derived from mouse liver tissue at 50 ug/lane (from 5 individual mice) loaded onto SDS-PAGE, transferred onto a NC membrane, then blotted by Rabbit anti-FAH antibody at 1:500. An immunoreactive band FAH protein is observed around ~47kD.

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  IHC: The mouse liver tissue was fixed and stained by Rabbit anti-FAH at 2 ug/ml for 37oC, 30 min, followed by HRP-linked secondary antibody, and visualized by AEC substrate, and counterstaining by hematoxylin.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A full length recombinant protein of FAH from mouse origin
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: ~47 kDa
• Gene Name: fumarylacetoacetate hydrolase (fumarylacetoacetase)
• Database Link:
  NP_000128
  Entrez Gene 14085 MouseEntrez Gene 29383 RatEntrez Gene 2184 Human
  UniProt ID P16930
• Background: Fumarylacetoacetate hydrolase, also known as FAH, is an enzyme that catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. It is the last enzyme in tyrosin catabolism pathway. This enzyme is abundant in the liver and kidney, and smaller amounts are found in many tissues throughout the body. Human genetic disorder hereditary tyrosinemia (HT) is associated with FAH deficiency and liver/ kidney dysfunction.
• Synonyms: FLJ51912

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Tyrosine metabolism