ER81 (ETV1) Rabbit Polyclonal Antibody

CAT#: TA354754

Rabbit anti ER81 Polyclonal Antibody

Product Images

WB: The tissue lysate derived from mouse brain was immunoprobed by Rabbit anti-ER81 at 1:500. An immunoreactive band is observed around ~56kDa (lane 1). This band is blocked by pre-incubation with immunizing peptide (Lane 2)

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the C-terminus of human ER81 protein. This sequence is identical within human, rat, mouse, bovine, dog and chicken.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 56 kDa
• Gene Name: ETS variant 1
• Database Link:
  NP_004947
  Entrez Gene 14009 MouseEntrez Gene 362733 RatEntrez Gene 2115 Human
  UniProt ID P50549
• Background: The ETS transcription factors Ets2, ER81 and Elk1 belong to the Ets transcription factor family. ER81 (also designated ETV1) binds the motif 5'-CGGAA/T-3'. It is a prerequisite for normal development. An abnormal regulation contributes to neoplasia. ER81 is highly expressed in brain, testis, lung and heart. ER81 is also moderately expressed in spleen, pancreas, colon and small intestine. During development, ER81, PEA3 and ERM display unique expression patterns which suggest these transcriptional factors play an important role in organogenesis. ERK-1 activates ER81 transcriptional activity while MAPKAP kinase 2 inhibits ER81. ER81 also can be acetylated at N-terminus (Lys33 and Lys116).
• Synonyms: ER81

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Transcription Factors