SOCS5 Rabbit Polyclonal Antibody

CAT#: TA354824

Rabbit anti SOCS-5 Polyclonal Antibody

Product Images

WB: The tissue lysates derived from mouse liver was immunoprobed by Rabbit anti-SCOS-5 antibody at 1:500. An immunoreactive band is observed around ~60 kDa.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 0.5-2 µg/ml FC Not tested
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the C-terminus of SOCS-5 protein from human, mouse and rat origins.
• Formulation: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 60 kDa
• Gene Name: suppressor of cytokine signaling 5
• Database Link:
  NP_054730
  Entrez Gene 56468 MouseEntrez Gene 9655 Human
  UniProt ID O75159
• Background: Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS5 regulates IL-4 signaling through JAK1 negatively.
• Synonyms: CIS6; Cish5; CISH6; SOCS-5

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Jak-STAT signaling pathway