Estrogen Receptor 1 (ESR1) Rabbit Polyclonal Antibody

CAT#: TA354835

Rabbit anti ER(pS305) Polyclonal Antibody


USD 355.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide surrounding the epitope –KNSLA- with a phosphorylation site of Ser305 of human estrogen receptor.
Formulation This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 67 kDa
Gene Name estrogen receptor 1
Background ER (estrogen receptor) belongs to a member of the steroid receptor superfamily. It contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by its phosphorylation at multiple sites, such as serine 104, 106, 118, 167 and 305. Phosphorylation of certain serine at ER may relate to breast cancer process and on-going treatment.
Synonyms ER; Era; ESR; ESRA; ESTRR; NR3A1
Reference Data
Protein Families Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.